O Brother, Where Art Thou? is a 2000 comedy drama film written, produced, co-edited, and directed by Joel and Ethan Coen; it stars George Clooney, John Turturro, and Tim Blake Nelson. Chris Thomas King, John Goodman, Holly Hunter, and Charles Durning have supporting roles in the cast.

The film is set in 1937 rural Mississippi during the Great Depression. Its story is a modern satire loosely based on Homer's epic Greek poem the Odyssey that incorporates social features of the American South. The title of the film is a reference to the Preston Sturges 1941 film Sullivan's Travels, in which the protagonist is a director who wants to film O Brother, Where Art Thou?, a fictitious book about the Great Depression.